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“Tissue Chips in Space”
NIH-Funded Tissue Chip Investigations to Fly on SpaceX CRS-25 Mission to the ISS
Tissue chips for a UCSF investigation are prepared for launch to the ISS onboard Space CRS-25. (Credit: Sonja Schrepfer, University of California, San Francisco)

KENNEDY SPACE CENTER, Fla. (CASIS PR) – In the absence of effective countermeasures, prolonged spaceflight can result in many of the same physiological changes associated with aging—bone loss, muscle deterioration, and altered immune system function—only at a much quicker rate. This makes the microgravity environment of the International Space Station (ISS) a valuable platform for research on conditions associated with the aging process.

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  • July 11, 2022
Emulate Brain-Chip to Study the Effects of Microgravity on Human Brain Physiology at the International Space Station

BOSTON, December 21, 2021 (Emulate PR) – Emulate, Inc., a leading provider of next-generation in vitro models, today announced that the Brain-Chip was sent to the International Space Station U.S. National Laboratory (ISS National Lab) to study the effects of microgravity on human brain physiology as part of the Tissue-Chips in Space initiative sponsored by the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) and the International Space Station National Lab (ISS-NL). The ISS provides an environment where researchers can study human health in microgravity, allowing them to isolate the effects of gravity from other factors that can impact brain cell function. 

The Emulate Brain-Chip is the most comprehensive in vitro model of the human neurovascular unit, including the blood-brain barrier (BBB), for preclinical research. It contains five cell types in a dynamic and tunable microenvironment, resulting in in vivo-like gene expression and phenotypic response. Each chip is about the size of a USB thumb drive and contains two fluidic channels separated by a porous membrane. The vascular channel is lined with brain microvascular endothelial cells, while the brain channel contains cortical neurons, astrocytes, pericytes, and microglia. This allows researchers to study BBB function, the ability of drugs to cross the BBB, and the complex cell-cell interactions involved in brain physiology, disease, and drug response.

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  • December 28, 2021
SpaceX’s 22nd Commercial Resupply Mission to Space Station Launches Water Bears, Squids, Solar Panels
These immature bobtail squid (Euprymna scolopes) are part of UMAMI, an investigation that examines whether space alters the symbiotic relationship between the squid and the bacterium Vibrio fischeri. (Credits: Jamie S. Foster, University of Florida)

HOUSTON (NASA PR) — The 22nd SpaceX cargo resupply mission carrying scientific research and technology demonstrations launches to the International Space Station from NASA’s Kennedy Space Center in Florida no earlier than June 3. Experiments aboard include studying how water bears tolerate space, whether microgravity affects symbiotic relationships, analyzing the formation of kidney stones, and more.

Highlights of the payloads on this resupply mission include:

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  • May 24, 2021
SpaceX Crew-2 Astronauts Will Perform a Wide Variety of Research During Six-Month Mission

KENNEDY SPACE CENTER, Fla., April 26, 2021 (CASIS PR) – Early Friday morning, NASA’s SpaceX Crew-2 mission launched four astronauts to the International Space Station (ISS) from Kennedy Space Center’s Launch Pad 39A. After a successful launch of the Falcon 9 rocket into low Earth orbit, the SpaceX Crew Dragon trailed the orbiting laboratory until Saturday morning, when the spacecraft successfully docked. On this mission, the second under NASA’s Commercial Crew Program, NASA astronauts Shane Kimbrough and Megan McArthur, Japanese Aerospace Exploration Agency astronaut Akihiko Hoshide, and European Space Agency astronaut Thomas Pesquet joined the other members of the ISS Expedition 65 crew.

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  • April 26, 2021
SpaceX CRS-21 Safely Splashes Down Off the Coast of Florida, Returning Science From the Space Station Back to Earth

KENNEDY SPACE CENTER, Fla., January 14, 2021 (CASIS PR)  – SpaceX’s Dragon spacecraft splashed down safely off the coast of Florida last night, concluding a month-plus stay at the International Space Station (ISS) to bring back thousands of pounds of scientific research and cargo.

With this successful splashdown, SpaceX completed its 21st Commercial Resupply Services (CRS) mission to the orbiting laboratory for NASA. This also marks the first mission of the upgraded Dragon cargo spacecraft with double the powered locker capacity of previous capsules, allowing for even more research to travel back to Earth for analysis.

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  • January 15, 2021
NASA Astronauts Hard at Work on Multiple Life Science Investigations Aboard the International Space Station
International Space Station (Credit: NASA/Roscosmos)

KENNEDY SPACE CENTER, Fla. (CASIS PR) – On December 7th, a Dragon spacecraft loaded with thousands of pounds of critical supplies and research docked with the International Space Station (ISS), paving the way for an incredibly busy Expedition 64 dedicated to executing science on the orbiting laboratory.

SpaceX’s 21st commercial resupply services (CRS-21) mission to the ISS brought with it a variety of life science investigations sponsored by the U.S. National Laboratory that will be evaluated in the unique microgravity environment, intending to benefit patient care on Earth. Since Dragon’s arrival, the astronauts have been hard at work performing many of these investigations.

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  • December 22, 2020
Hearts, Airlocks and Asteroids: New Research Flies on 21st SpaceX Cargo Mission

HOUSTON (NASA PR) — The 21st  SpaceX cargo resupply mission that launches from NASA’s Kennedy Space Center in Florida carries a variety of critical research and technology demonstrations to the International Space Station. The mission represents the first on an upgraded version of the company’s Dragon cargo spacecraft designed to carry more science payloads to and from the space station.

Highlights of the payloads on this mission include:

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  • November 19, 2020
Crew-1 Heads to Space Station to Conduct Microgravity Science
NASA astronauts Shannon Walker, left, Victor Glover, second from left, Mike Hopkins, second from right, and Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, right, are introduced by Kennedy Space Center Director Bob Cabana after arriving at the Launch and Landing Facility at NASA’s Kennedy Space Center ahead of SpaceX’s Crew-1 mission, Sunday, Nov. 8, 2020, in Florida. (Credit: NASA/Joel Kowsky)

HOUSTON (NASA PR) — Expedition 1 and Crew-1. These historic International Space Station missions lifting off 20 years apart share the same goals: advancing humanity by using the space station to learn how to explore farther than ever before, while also conducting research and technology demonstrations benefiting life back on Earth.

Crew-1, made up of NASA astronauts Shannon Walker, Victor Glover, and Mike Hopkins, and Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, continues the legacy of two decades of living and working in low-Earth orbit by becoming space scientists for the next six months.

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  • November 14, 2020